Long non-coding RNA LINC00641 promotes the growth and invasiveness of hepatocellular carcinoma by antagonizing miR-501-3p

Introduction Long non-coding RNA LINC00641 has been reported to regulate tumor progression in several cancers. However, the expression and function of hepatocellular carcinoma (HCC) is still unclear. Material methods In this study, we measured 79 pairs HCC adjacent normal liver tissues. The clinical significance was explored. We also investigated proliferation invasion. Results observed that significantly increased relative tissues (P < 0.0001). High associated with vascular invasion, advanced TNM stage, reduced overall survival patients. Knockdown inhibited proliferation, colony formation, invasion cells. contrast, overexpression promoted cell growth invasiveness. vivo studies confirmed knockdown restrained tumorigenesis Mechanistic revealed miR-501-3p, which previously act as a suppressor HCC. Furthermore, luciferase reporter assays validated harbored target site for miR-501-3p. Rescue experiments demonstrated LINC00641-induced cells reversed by co-expression Conclusions Taken together, contributes aggressive phenotype sponging miR-501-3p represents promising therapeutic disease.